LIN28B/let-7control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling
نویسندگان
چکیده
منابع مشابه
Notch signaling and the emergence of auditory hair cells.
OBJECTIVE Recent insights into the mechanisms that determine a hair cell's fate have emerged from studies on invertebrate sensory organs and the avian inner ear. These mechanisms have important implications for our understanding of the possible therapeutic management of sensorineural deafness. This article reviews the current state of our knowledge regarding mammalian auditory hair cell fate sp...
متن کاملLgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea
The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound. Here, we show that supporting cells, which surround hair cells in the normal cochlear epithelium, differentiate into new hair cells in the neonatal mouse following ototoxic damage. Using lineage tracing, we sho...
متن کاملCurcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway
Objective(s): The aim of this study was to investigate the effect of curcumin on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying potential mechanism.Materials and Methods: The tissue explant adherence method was used to isolate hPDLSCs. Flowcytometry, Alizarin Red staining and Oil Red ...
متن کاملCochlear Hair Cells and Supporting Cells in Organ of Corti
ered essential for establishment of high K+ concentration in endolymph and the endocochlear potential (36, 109). The concept of the K+ circulation was originally proposed from observations that 1) radioactive K+ applied to perilymph could be detected in endolymph much more efficiently than when perfused to blood plasma (40, 84) and 2) perilymphatic but not vascular perfusion of K+-free solution...
متن کاملCochlear Hair Cells and Supporting Cells in Organ of Corti
ered essential for establishment of high K+ concentration in endolymph and the endocochlear potential (36, 109). The concept of the K+ circulation was originally proposed from observations that 1) radioactive K+ applied to perilymph could be detected in endolymph much more efficiently than when perfused to blood plasma (40, 84) and 2) perilymphatic but not vascular perfusion of K+-free solution...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2000417117